A Novel Effect of Cochlear Efferents: In Vivo Response Enhancement Does Not Require 9 Cholinergic Receptors
نویسندگان
چکیده
Stéphane F. Maison, Douglas E. Vetter, and M. Charles Liberman Department of Otology and Laryngology, Harvard Medical School and Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston; Tufts University School of Medicine, Department of Neuroscience, Boston; and Division of Health Science and Technology, Harvard University/Massachusetts Institute of Technology, Cambridge, Massachusetts
منابع مشابه
A novel effect of cochlear efferents: in vivo response enhancement does not require alpha9 cholinergic receptors.
Outer hair cells in the mammalian cochlea receive a cholinergic efferent innervation that constitutes the effector arm of a sound-evoked negative feedback loop. The well-studied suppressive effects of acetylcholine (ACh) release from efferent terminals are mediated by alpha9/alpha10 ACh receptors and are potently blocked by strychnine. Here, we report a novel, efferent-mediated enhancement of c...
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Centrifugal crossed and uncrossed medial olivocochlear systems (CMOCS and UMOCS) terminate on cochlear outer hair cells (OHCs) and exercise effects through a nicotinic cholinergic receptor. Hence their cochlear effects have not been differentiated. Recent work on protection from loud-sound-induced temporary threshold shifts (TTSs) in hearing sensitivity suggest the two OHC efferent systems may ...
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The main source of excitation to the ventral cochlear nucleus (VCN) is from glutamatergic auditory nerve afferents, but the VCN is also innervated by two groups of cholinergic efferents from the ventral nucleus of the trapezoid body. One arises from collaterals of medial olivocochlear efferents, and the other arises from neurons that project solely to the VCN. This study examines the action of ...
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تاریخ انتشار 2007